Quantum-enhanced estimation of stimulated Raman optical activity
Source: Originally published on arXiv quant-ph on June 24, 2026.
arXiv:2606.23722v1 Announce Type: new Abstract: In recent times there has been growing interest in Raman optical activity (ROA) for its label free detection of absolute configuration, conformation, and stereochemical structure in chiral biosamples and drug molecules. Since ROA signals are generally small, techniques such as stimulation by a probe beam can be used to enhance the signal strength. However, with a classical probe, the measurement precision is still fundamentally limited by its shot noise. To solve this problem we propose the use of two-mode squeezed vacuum and show that it can achieve sub-shot noise limited measurement sensitivity. Using quantum estimation theory, we derived the quantum Fisher information and the quantum Cram'er-Rao bound (QCRB) for stimulated ROA measurement...
To read the full article, visit the original source page: